Inhibition of methylcholanthrene carcinogenesis by hypophysectomy.
نویسندگان
چکیده
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منابع مشابه
Further observations on the role of the pituitary and the adrenal gland in azo dye carcinogenesis.
Several investigators have observed that the pituitary exerts an effect on carcinogenesis and also on the growth of tumors. Ferguson and Visscher (1) found that hypophysectomy pre vented the development of postcastration adrenal cortical nodular hyperplasia in C3H mice. Moon and associates (7-9) reported that the administra tion of growth hormone to female rats (LongEvans strain) resulted in tu...
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The presence of benzpyrene hydroxylase activity in the small intestine, lung, and kidney of the normal rat has been shown by quantitative assay and compared with the level of activity in the liver. The intraperitoneal injection of methylcholanthrene in creased the level of activity found in each of the four tissues examined. The stimu lation by methylcholanthrene was inhibited by the simultaneo...
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Chronic p.o. feeding of small amounts of ellagic acid, a naturally occurring dietary plant phenol, to BALB/c mice in drinking water afforded significant protection against skin tumorigenesis induced by 3-methylcholanthrene, a polycyclic aromatic hydrocarbon carcinogen. A significant increase in the latent period for the development of skin tumors by 3-methylcholanthrene was observed in the ella...
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عنوان ژورنال:
- Science
دوره 116 3013 شماره
صفحات -
تاریخ انتشار 1952